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1 AUC values shown in this table were calculated directly from each participants concentration-time data using noncompartmental methods, and therefore differ from the model-based estimated mean AUCs reported elsewhere in the manuscript, which were obtained from linear mixed-effects models fitted on log-transformed AUC and back-transformed to the original scale (estimated marginal means)

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10.1016/j.cbpa.2017.11.003 116 RuizL